Psychedelics online

Psychedelics online LSD Proven Safe in Landmark Trial

Psychedelics online despite its vast potential, LSD has been mostly off-limits to scientists for half a century, declared highly dangerous, even in small doses.

But Psychedelics online landmark placebo-controlled clinical trial found micro doses of LSD are physically safe, easing the drug’s path forward as a medicine.

Researchers in London with Eleusis, a private life-sciences company, asked 48 healthy, older adults without significant health problems to take 5, 10, or 20 micrograms every four days for three weeks — basically the Fadiman Protocol.

Psychedelics online other studies have looked at micro dosing’s affect on mood and cognition, with inconclusive results. This Phase 1 Psychedelics online study, in contrast, monitored all aspects of micro dozers’ health, from blood pressure to heart rates and rhythms to walking, talking, memory, and perception.

Micro dozers, researchers found, had no more negative side effects than a placebo. Cognition, balance, and coordination were not impaired — although micro dozers reported more headaches.

“The study provides reassuring safety data,” said Robin Carhart-Harris, head of the Centre for Psychedelic Research at Imperial College London, “and opens the door for larger scale clinical trials to evaluate the potential therapeutic effects of LSD.”

Eleusis plans to carry out Phase 2 studies for LSD for Alzheimer’s and other degenerative diseases.

Studies of micro dosing signal an expansion of the possibilities for psychedelics in the West, which burst into the scene in the 50s and 60s as a mind-expanding, culture-shaking bombshell, favored by monks and mystics plumbing the nature of mind and soul.

Psychonauts still seek God and Nature through psychedelics. But researchers also envision a whole new class of drugs aimed at dozens of psychological ailments. Psilocybin — a hallucinogen similar to LSD — has twice been declared a “breakthrough treatment” for depression when combined with therapy.

Less noticed has been psychedelics’ effects not on the mind and spirit, but the body. Long-distance runners and rock climbers report that LSD and mushrooms improve focus and lessen pain and fatigue.

So researchers are increasingly investigating the drugs’ effects on muscles and neurons. Focused on physical effects, Eleusis habitually calls them “serotonin 5-HT2A receptor agonists” — rather than psychedelics, hallucinogens, or entheogens.

Eleusis studies have found psychedelic-type drugs reduce inflammation in both mice with asthma and mice with a heart problem called coronary artery disease, which could lead to promising treatments of some of the most common health problems.

Serotonin receptors, which help regulate memory and cognition, degenerate in folks with Alzheimer’s, leading to some of the disease’s early signs, including depression and anxiety.

“Our research with serotonin 5-HT2A receptor agonists, such as LSD, suggest that they may represent a new strategy to treat diseases associated with chronic inflammation,” said Charles Nichols, co-author of the study and Professor of Pharmacology at Louisiana State University.

Eleusis’s studies hint at the intriguing possibility that healthy adults could take LSD the way they take Advil or aspirin — as a routine anti-inflammatory.

Micro dosing participants didn’t trip — didn’t feel “oceanic boundlessness,” synesthesia, or auditory hallucinations. They functioned normally.

But they did see the world differently in one fascinating way.

When shown a blue circle for a few seconds, then asked to guess how long the shape was visible, micro dozers overestimated the duration. The outside world, in other words, seemed to move more slowly.

Large doses of psychedelics famously dilate time; sunsets can seem to last for days. This study suggests micro dozers subjectively experience a few more moments in their day than the rest of us — even though they aren’t aware of it. (Results of this part of the study were published last year.)

Thanks to this study, time dilation —- and other effects of micro dosing — can now be studied more easily, and in more depth, clearing a path for clarity on whether micro dosing can be a helpful medicine for brain diseases, or add a few more microseconds to your day, possibly helping you find your flow.

“This groundbreaking Phase 1 trial,” said Shlomi Raz, Chairman and Founder of Eleusis, could help “unlock the therapeutic potential of psychedelics at subperceptual, non-psychoactive doses, to safely address the most urgent unmet needs in public health.”

Grow mushrooms

HOW TO GROW YOUR OWN MUSHROOMS

Grow mushrooms when it comes to ensuring the quality and safety of your mushrooms, DIY not only saves you money but eases the stress of securing a legitimate source. Not to mention, supporting to grow mushrooms on every step of their journey allows you to connect deeper with nature while creating self-reliance through maintaining growing mushroom reservoir of your choice. We understand growing your own mushrooms may sound a little intimidating which is why we’ve put together an easy “how-to” on how to build your own personal fungi kingdom, right from your apartment.

Need a quick rundown of psilocybin? Head to our Psilocybin Mushrooms Ultimate Guide.

Supplies

Grow mushrooms you’ll need a few materials to get started but don’t worry, this set up only needs to be purchased one-time, and is significantly more economical in the long run than purchasing a grow kit or buying by the gram.

Ingredients to Grow mushrooms

  • Spore syringe, 10-12 cc
  • Organic brown rice flour
  • Vermiculite, medium/fine
  • Drinking water

Equipment

  • 12 Shoulderless half-pint jars with lids (e.g. Ball or Kerr jelly or canning jars)
  • Hammer and small nail
  • Measuring cup
  • Mixing bowl
  • Strainer
  • Heavy-duty tin foil
  • Large cooking pot with a tight lid, for steaming
  • Small towel (or approx. 10 paper towels)
  • Micropore tape
  • Clear plastic storage box, 50-115L
  • Drill with ¼-inch drill bit
  • Perlite
  • Mist spray bottle

Hygiene Supplies Grow mushrooms

  • Rubbing alcohol
  • Butane/propane torch lighter
  • Surface disinfectant
  • Air sanitizer

To learn more about which spore variety you should choose, check out our grow guide.

PF Tek Method Grow mushrooms

This method of mushroom cultivation is cheap and pretty straightforward, therefore, perfect for the newbie fungi farmer and experienced “fungiculturist” alike.  For this process, you’ll prepare your substrate of brown rice flour, vermiculite, and water, and divide it between sterile glass jars. This allows you to control humidity while introducing air to the substrate providing the perfect environment for the mycelium to grow. After you’ve prepared the jars and divided the substrate, you’ll then introduce the spores and wait for the mycelium to develop. After about 4-5 weeks, transfer your colonized substrates, or “cakes”, to a fruiting chamber where you’ll wait for your mushrooms to grow. Check out the full step by step process of the PK Tek Method including preparation, inoculation, and colonization.

Preparing the Grow Chamber

So at this point, you’ve discarded any contaminated materials and consolidated the jars of your successful mycelium. Now it’s time to prepare your fruiting chamber and begin the birth process of your “cakes” or colonized substrates.

Make a shotgun fruiting chamber

  • Take your plastic storage container and drill ¼-inch holes roughly two inches apart all over the sides, base, and lid. To avoid cracking, drill your holes from the inside out into a block of wood.
  • Set the box over four stable objects, arranged at the corners to allow air to flow underneath. You may also want to cover the surface under the box to protect it from moisture leakage.

Add perlite

  • Place your perlite into a strainer and run it under the cold tap to soak.
  • Allow it to drain until there are no drips left, then spread it over the base of your grow chamber.
  • Repeat for a layer of perlite roughly 4-5 inches deep.

Fruiting

    • Open your jars and remove the dry vermiculite layer from each, taking care not to damage your substrates, or “cakes”, in the process.
    • Upend each jar and tap down onto a disinfected surface to release the cakes intact.
  • Rinse the cakes one at a time under a cold tap to remove any loose vermiculite, again taking care not to damage them.
  • Fill your cooking pot, or another large container, with tepid water, and place your cakes inside. Submerge them just beneath the surface with another pot or similar heavy item.
  • Leave the pot at room temperature for up to 24 hours for the cakes to rehydrate.
  • Remove the cakes from the water and place them on a disinfected surface.
  • Fill your mixing bowl with dry vermiculite.
  • Roll your cakes one by one to fully coat them in vermiculite. This will help to keep in the moisture.

Transfer to grow chamber

  • Cut a tin foil square for each of your cakes, large enough for them to sit on without touching the perlite.
  • Space these evenly inside the grow chamber.
  • Place your cakes on top and gently mist the chamber with the spray bottle.
  • Fan with the lid before closing.

Optimize and monitor conditions

  • Mist the chamber around four times a day to keep the humidity up, taking care not to soak your cakes with water.
  • Fan with the lid up to six times a day, especially after misting, to increase airflow.

Harvesting

The hard work is over. You’re now ready to sit back, relax, and watch for fruits (while still optimizing and monitoring conditions, of course). Your mushrooms, or fruits, will appear as tiny white bumps before sprouting into “pins.” After 5-12 days, they’ll be ready to harvest. When ready, cut your mushrooms close to the cake to remove. Don’t wait for them to reach the end of their growth, as they’ll begin to lose potency as they mature. It may not sound like a walk in the park, but the money you’ll save, the peace of mind you’ll gain, and the experience you’ll have under your belt will prove well worth it. The best news is, you’ll be able to re-use the same cakes up to three times!

Now, all there is to do is enjoy the fruits of your labor and with the long-term benefits of psilocybin, micro dosing is a facile way to implement psilocybin into your routine. Many who have integrated micro dosing psilocybin mushrooms into their weekly routine report higher levels of creativity, more energy, increased focus, and improved relational skills, as well as reduced anxiety, stress, and even depression. To learn more about micro dosing check out our Ultimate Guide to Micro dosing Psilocybin Mushrooms. Growing your own mushrooms gives you the independence to gain ownership of your mental wellbeing we’ve got you covered from start to finish.

Need a more hands-on and guided approach? Our friends at Double Blind Mag teach you how to grow your own mushrooms with experienced mycology experts and support along every step of the way with their How To Grow Your Own Mushrooms course. Click here to get started.